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Shivering and trembling may be signs of the early stages of an overdose and can lead to a more serious seizure. Seizures can permanently damage brain cells, and some people will not survive them. Overuse of toxic substances is one of the reasons why the brain has abnormal electricity. When the brain is stopped from performing normal activity and becomes disrupted, electrical activity is deregulated and can cause cells to malfunction, throwing the body in convulsions, or seizures. The severe pressure on the brain caused by substance abuse, or a combination of substances, can cause loss of consciousness. When brain cells receive an overwhelming amount of toxins, they can shut down. Sometimes a person will exhibit violent and aggressive actions prior to losing all functioning. They can talk rapidly or nonsensically, lash out verbally and physically, stumble, fall, cry, or scream. When people are conscious they may not be aware of their surroundings or be able to physically keep their balance. Confusion and disorientation, accompanied by severe anxiety can also exhibit signs that a person is overdosing. Confusion and disorientation/violent behavior.Opioids tend to have the opposite effect, causing slower breathing and a reduced heart rate. An overly stressed heart can cause small muscle tears, resulting in bleeding and severe pain. Too many stimulants can cause rapid heart rate, and lead to heart pain and cardiac arrest. If the person is unconscious and vomits, unable to expel it from their mouth and windpipe, they may end up choking on it. In popular culture, people often associate dilated pupils with the experience of ingesting one of these substances. The effects of these drugs can range from 6 hours to 12 hours depending on the intake. Often a person will aspirate during an overdose, causing the body to respond by vomiting contents out of the system. Hallucinogens such as LSD, mescaline, and psilocybin can produce symptoms that include restlessness, sleep deprivation, and dilated pupils. This is a direct sign from lack of oxygen in the body an means the person is close to expiring. Some people experience a rise in body temperature during an overuse of substances, though it is common to see a body change in color as their body temperature will drop, turning lips and extremities to a blueish color. When the body is in a state of emergency, or if the air passages become blocked, it will often exhibit slow difficult breathing combined with rapid breathing, or gasping for air, as in an attempt to regulate. When using narcotics including heroin, morphine, hydrocodone, and fentanyl, a person’s pupils will constrict, while other drugs such as cocaine make pupils dilate and become larger. Depending on which type of substance used, pupils can change in size or show a rapid quivering effect called nystagmus. People who are experiencing a drug overdose may not have all of these signs, but if they are exhibiting a few, it may indicate a probability that they are overdosing.